The impact of total parenteral nutrition on liver function tests in patients with cancer

Abstract Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO2/FiO2 < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.

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Prevalence, outcome and associated factors of deranged liver function tests in patients on home parenteral nutrition

Clinical Nutrition ◽

10.1054/clnu.2002.0554 ◽

2002 ◽

Vol 21 (4) ◽

pp. 337-343 ◽

Cited By ~ 88

Author(s):

W. LUMAN ◽

J.L. SHAFFER

Keyword(s):

Liver Function ◽

Parenteral Nutrition ◽

Associated Factors ◽

Liver Function Tests ◽

Home Parenteral Nutrition ◽

Function Tests

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Diagnosis experiences from 50 hepatitis B patients in Chongqing, China: a qualitative study

BMC Public Health ◽

10.1186/s12889-021-11929-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiangxi Zhou ◽

Fan Zhang ◽

Yongping Ao ◽

Chunli Lu ◽

Tingting Li ◽

...

Keyword(s):

Hepatitis B ◽

Liver Function ◽

Healthy Lifestyle ◽

Signs And Symptoms ◽

Liver Function Tests ◽

Irreversible Damage ◽

Function Tests ◽

Professional Mental Health ◽

The Impact

Abstract Background The aim of this study was to provide recommendations for reducing the impact of hepatitis B infection on patients with chronic hepatitis B by describing their experiences during the diagnosis process. Methods We conducted face-to-face interviews with 50 hepatitis B patients recruited by convenient sampling from an infectious diseases department of a teaching hospital in Chongqing, China from July to August 2019. Thematic analysis framework included interviewees’ social demographic characteristics, diagnosis approach, signs and symptoms before diagnosis, feelings after diagnosis, and doctor’s instructions. Results Most patients first detected hepatitis B through various types of physical examinations when the patients were asymptomatic or had only mild symptoms. Most patients were shocked, scared, or overwhelmed when they were diagnosed with hepatitis B. They were able to remember the doctor’s instructions about maintaining a healthy lifestyle, but not impressed by the doctor’s advice about regular follow-up liver function tests. The lack of regular follow-up has caused irreversible damage to some patients. Conclusions Most patients are passively diagnosed with hepatitis B due to their lack of awareness on active hepatitis B prevention. Patients need professional mental health care to overcome the negative emotions that following the diagnosis. Physicians’ instruction should emphasize the importance of regular follow-up liver function tests in addition to a healthy lifestyle.

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